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SMAD3

Gene
Official SymbolSMAD3
Official NameSMAD family member 3
BirdBase IDBB-GG17798
CGNC ID5954
also known asmothers against decapentaplegic homolog 3|MAD homolog 3|SMAD 3|SMAD, mothers against DPP homolog 3|TGF-beta response effector Smad3|mad3|mothers against DPP homolog 3, SMAD3
gene typeprotein-coding
Genomic Map
Ensembl ID not known
NCBI
UCSC
Gallus-Browse
Sequence Information
GenomicGenbank
RNANM_204475
PolypeptideNP_989806
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
UnigeneGga.28197
Microarray
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Zebrafish326283, 58092ENSDARG00000010207, ENSDARG00000036096ZDB-GENE-030128-4, ZDB-GENE-000509-3ZFIN:ZDB-GENE-030128-4, ZFIN:ZDB-GENE-000509-3
Xenopus493272, 378633481991
Mouse17127ENSMUSG00000032402All phenotypic alleles (7):Targeted, knock-out(3) Targeted, other(4) MGI:1201674
Human4088ENSG00000166949MIM:613795MIM:603109
Gene Ontology
Molecular Functionbeta-catenin binding, chromatin DNA binding, core promoter proximal region sequence-specific DNA binding, co-SMAD binding, phosphatase binding, protein binding transcription factor activity, protein homodimerization activity, protein kinase binding, RNA polymerase II activating transcription factor binding, R-SMAD binding, sequence-specific DNA binding transcription factor activity, transforming growth factor beta receptor binding, transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity, ubiquitin binding, ubiquitin protein ligase binding, zinc ion binding
Biological Processactivation of cysteine-type endopeptidase activity involved in apoptotic process, cell-cell junction organization, cell cycle arrest, evasion or tolerance of host defenses by virus, extrinsic apoptotic signaling pathway, immune response, negative regulation of cell growth, negative regulation of inflammatory response, negative regulation of mitotic cell cycle, negative regulation of osteoblast proliferation, negative regulation of protein catabolic process, negative regulation of protein phosphorylation, negative regulation of wound healing, nodal signaling pathway, osteoblast differentiation, positive regulation of canonical Wnt signaling pathway, positive regulation of catenin import into nucleus, positive regulation of chondrocyte differentiation, positive regulation of epithelial to mesenchymal transition, positive regulation of gene expression involved in extracellular matrix organization, positive regulation of transcription, DNA-templated, positive regulation of transcription factor import into nucleus, protein stabilization, regulation of immune response, regulation of transforming growth factor beta2 production, response to hypoxia, T cell activation, transcription, DNA-templated, transforming growth factor beta receptor signaling pathway, transport, ureteric bud development
Cellular Componentcytoplasm, nuclear inner membrane, nucleus, receptor complex, SMAD protein complex, transcription factor complex
Literature
eGIFT Analysis
Links to other databases
Entrez Gene395132
Ensembl Gene
KEGGgga:395132