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GREM1

Gene
Official SymbolGREM1
Official Namegremlin 1, DAN family BMP antagonist
BirdBase IDBB-GG4307
CGNC ID49499
also known asDrm, gremlin-1|Down-regulated by v-mos|gremlin 1 homolog, cysteine knot superfamily|gremlin 1, cysteine knot superfamily, homolog, Gremlin-1, drm
gene typeprotein-coding
Genomic Map
Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
GenomicGenbank
RNANM_204978
PolypeptideNP_990309
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
UnigeneGga.2961
Microarray
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Zebrafish100332287, 100005728, 405778, 100271673ENSDARG00000070612, ENSDARG00000029546ZDB-GENE-040625-1, ZDB-GENE-090218-21ZFIN:ZDB-GENE-040625-1, ZFIN:ZDB-GENE-090218-21
Xenopus100101711, 399094484542
Mouse23892All phenotypic alleles (8):Spontaneous(1) Radiation induced(1) Targeted, knock-out(1) Targeted, other(5) MGI:1344337
Human26585MIM:603054
Gene Ontology
Molecular Functioncytokine activity, protein tyrosine kinase activator activity, receptor agonist activity, vascular endothelial growth factor receptor 2 binding
Biological Processbranching involved in ureteric bud morphogenesis, cell-cell signaling, cell migration involved in sprouting angiogenesis, collagen fibril organization, determination of dorsal identity, embryonic limb morphogenesis, mesenchymal to epithelial transition involved in metanephros morphogenesis, negative regulation of BMP signaling pathway, negative regulation of bone mineralization involved in bone maturation, negative regulation of bone remodeling, negative regulation of bone trabecula formation, negative regulation of branching involved in ureteric bud morphogenesis, negative regulation of canonical Wnt signaling pathway, negative regulation of osteoblast proliferation, negative regulation of osteoclast proliferation, negative regulation of pathway-restricted SMAD protein phosphorylation, negative regulation of transcription, DNA-templated, positive regulation of angiogenesis, positive regulation of branching involved in ureteric bud morphogenesis, positive regulation of cardiac muscle cell differentiation, positive regulation of cell proliferation, positive regulation of NF-kappaB import into nucleus, positive regulation of NF-kappaB transcription factor activity, positive regulation of peptidyl-tyrosine autophosphorylation, positive regulation of receptor internalization, positive regulation of telomerase activity, positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation, proximal/distal pattern formation, regulation of epithelial to mesenchymal transition, regulation of focal adhesion assembly, ureteric bud formation
Cellular Componentcell surface, extracellular space
Literature
Links to other databases
Entrez Gene395826
Ensembl GeneENSGALG00000009724
KEGGgga:395826