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ISL1

Gene
Official SymbolISL1
Official NameISL LIM homeobox 1
BirdBase IDBB-GG4992
CGNC ID11048
also known asISL-1, ISLET-1, insulin gene enhancer protein ISL-1|ISL1 transcription factor, LIM/homeodomain, (islet-1)|domesticus (clone 1.7 kB) islet-1
gene typeprotein-coding
Genomic Map
Ensembl
NCBI
UCSC
Gallus-Browse
Sequence Information
GenomicGenbank
RNANM_205414
PolypeptideNP_990745
Sequence Clusters/ESTsUnigene
Gene Expression
In Situ HybridizationGEISHA
UnigeneGga.1507
Microarray
Orthology
Entrez GeneEnsembl GeneGenetic PhenotypesMOD
Zebrafish30147ENSDARG00000004023ZDB-GENE-980526-112ZFIN:ZDB-GENE-980526-112
Xenopus549474, 100126604481335
Mouse16392ENSMUSG00000042258All phenotypic alleles (12):Targeted, knock-out(2) Targeted, other(10) MGI:101791
Human3670ENSG00000016082MIM:600366
Gene Ontology
Molecular FunctionbHLH transcription factor binding, enhancer sequence-specific DNA binding, RNA polymerase II activating transcription factor binding, RNA polymerase II transcription coactivator activity, sequence-specific DNA binding transcription factor activity, zinc ion binding
Biological Processatrial septum morphogenesis, cardiac cell fate determination, cardiac right ventricle morphogenesis, endocardial cushion morphogenesis, innervation, negative regulation of inflammatory response, negative regulation of neuron apoptotic process, negative regulation of transcription, DNA-templated, negative regulation of transcription from RNA polymerase II promoter, neuron fate specification, outflow tract septum morphogenesis, peripheral nervous system neuron axonogenesis, pharyngeal system development, positive regulation of angiogenesis, positive regulation of granulocyte colony-stimulating factor production, positive regulation of granulocyte macrophage colony-stimulating factor production, positive regulation of interferon-gamma production, positive regulation of interleukin-12 production, positive regulation of interleukin-1 alpha production, positive regulation of interleukin-1 beta production, positive regulation of interleukin-6 production, positive regulation of tumor necrosis factor production, positive regulation vascular endothelial growth factor production, secondary heart field specification, sensory system development, trigeminal nerve development, ventricular cardiac muscle tissue morphogenesis
Cellular Componentnucleus
Literature
eGIFT Analysis
Links to other databases
Entrez Gene396383
Ensembl GeneENSGALG00000014884
KEGGgga:396383